Welcome to the Lee Sherick Lab
Dr. Lee-Sherick is a Pediatric Bone Marrow Transplant specialist at Children's Hospital Colorado. Dr. Lee Sherick's primary research focus is to harness the immune system to more effectively cure acute leukemia. The Lee Sherick lab explores the role that tolerogenic macrophages and dendritic cells play in immune evasion of leukemia and how this can be reversed. One such approach is by inhibiting efferocytosis by blocking phosphatidyl serine receptors (such as MerTK) on macrophages and dendritic cells, which results in an anti-tumor microenvironment and decreases immune evasion. The hope is that the knowledge gained from this research can be used to develop novel immunotherapeutic approaches to treat acute leukemias.
McCubbrey AL, Allison KC, Lee-Sherick AB, Jakubzick CV, Janssen WJ.
Frontiers in Immunology Nov 24 2017; 8:1618; DOI: 10.3389/fimmu.2017.01618
Sufit A, Lee-Sherick AB, DeRyckere D, Rupji M, Dwivedi B, Varella-Garcia M, Pierce AM, Kowalski J, Wang X, Frye SV, Earp HS, Keating AK, Graham DK.
PLoS ONE October 26 2016; 11 (10):e0165107; DOI: 10.1371/journal.pone.0165107
DeRyckere D, Lee-Sherick AB, Huey MG, Hill AA, Tyner JW, Jacobsen KM, Page LS, Kirkpatrick GG, Eryildiz F, Montgomery SA, Zhang W, Wang X, Frye SV, Earp HS, Graham DK.
Clin Cancer Res March 15 2017; (23) (6) 1481-1492; DOI: 10.1158/1078-0432.CCR-16-1330
Lee-Sherick AB, Eisenman KM, Sather S, McGranahan A, Armistead PM, McGary CS, Hunsucker SA, Schlegel J, Martinson H, Cannon C, Keating AK, Earp HS, Liang X, DeRyckere D, Graham DK.
Oncogen September 5, 2016; 35 (48): 6270; DOI: 10.1038/onc.2016.295
Minson KA, Smith CC, DeRyckere D, Libbrecht C, Lee-Sherick AB, Huey MG, Lasater EA, Kirkpatrick GD, Stashko MA, Zhang W, Jordan CT, Kireev D, Wang X, Frye SV, Earp HS, Shah NP, Graham DK.
JCI Insight March 17, 2016; 1 (3): e85630; DOI: 10.1172/jci.insight.85630
Lee-Sherick AB, Zhang W, Menachof KK, Hill AA, Rinella S, Kirkpatrick G, Page LS, Stashko MA, Jordan CT, Wei Q, Liu J, Zhang D, DeRyckere D, Wang X, Frye S, Earp HS, Graham DK.
Oncotarget March 30, 2015; 6 (9): 6722-6736;
Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini C, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WHA, Porter CC, Di Paola J.
Nature Genetics March 25, 2015; 47 (5): 535-538; DOI: 10.1038/ng.3253
Christoph S, Lee-Sherick AB, Sather S, DeRyckere D, Graham DK.
Journal of Visualized Experiments September 18, 2013; (79): 50720; DOI: 10.3791/50720
Linger RM, Lee-Sherick AB, DeRyckere D, Cohen RA, Jacobsen KM, McGranahan A, Brandão LN, Winges A, Sawczyn KK, Liang X, Keating AK, Tan AC, Earp HS, Graham DK.
Blood August 29, 2013; 122 (9): 1599-609; DOI: 10.11.82/blood-2013-478156
Lee-Sherick AB, Linger RM, Gore L, Keating AK, Graham DK.
British Journal of Haematology August 31, 2010; 151 (4): 295-311; DOI: 10.1111/j.1365-2414.2010.08282.x
Lee AB, Harker-Murray P, Ferrieri P, Schleiss MR, Tolar J.
Pediatric Blood Cancer January 9, 2008; 50 (3): 673-6; DOI: 10.1002/pbc21286
Wang H, Grzywacz B, Sukovich D, McCullar V, Cao Q, Lee AB, Blazar BR, Cornfield DN, Miller JS, Verneris MR.
Blood September 1, 2007; 110 (5): 1530-9; DOI: 10.1182/blood-2006-048173
EDUCATION and TRAINING
University of Colorado (Children's Hospital Colorado) Program, Pediatric Hematology/Oncology
Oregon Health & Science University, Pediatrics
Children's Hospital of Orange County Program
MD, University of Minnesota Medical School
GRANTS and AWARDS
Professional Research Assistant
Kristen graduated from the University of Kansas with degrees in biochemistry and French. She is planning to apply for veterinary school in the near future.
Jane Koo, MD
2nd year Fellow Pediatric Hematology-Oncology
Jane is a fellow beginning her research with the Lee Sherick Laboratory focusing on the role of MerTK and macrophages in the setting of solid tumors. She completed her residency at the University of California at San Francisco Medical School and her medical education at the University of California, San Diego.